Ubiquitin, lysosomes, and neurodegenerative diseases.
نویسندگان
چکیده
Ubiquitin, lysosomes and neurodegenerative diseases R. John Mayer, Lajos Laszlo, Aliya Middleton, Michael Landon, James Hope* and James Lowet Departments of Biochemistry and Pathology,? University of Nottingham Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, U.K. and AFRUMRC Neuropathogenesis Unit,” Ogston Building, King’s Building Site, West Mains Road, Edinburgh EH9 3JF, Scotland, U.K.
منابع مشابه
VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.
Rupture of endosomes and lysosomes is a major cellular stress condition leading to cell death and degeneration. Here, we identified an essential role for the ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy. Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme...
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عنوان ژورنال:
- Biochemical Society transactions
دوره 20 3 شماره
صفحات -
تاریخ انتشار 1992